Jefferson County is located in the eastern portion of the state of Missouri. As of the 2010 census, the population was 218,733, making it the sixth-most populous county in Missouri. Its county seat is Hillsboro. The county was organized in 1818 and named in honor of former president Thomas Jefferson.
In 1980, according to the U.S. census held that year, the county contained the mean center of U.S. population. Notably, this was the first census in which the center of population was west of the Mississippi River.
Jefferson County is part of the St. Louis Metropolitan Statistical Area and encompasses many of the city’s southern suburbs.